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Malignant eccrine poroma
Mahmoud S Al-Ahwal1, Ali S Sawan, Sameer K Zimmo
1Department of Medicine, King Abdul-Aziz University Hospital, PO Box 80215, Jeddah 21589, Kingdom of Saudi Arabia. msa1959@hotmail.com
Saudi Medical Journal
|June 14, 2005
Summary
Malignant transformation of benign eccrine poroma is rare but can occur, presenting aggressively with recurrence and lymph node involvement. Management of metastatic disease remains challenging due to treatment resistance.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Benign eccrine poroma originates from the intraepidermal eccrine duct.
- Malignant transformation is uncommon, often indicated by symptoms like pain, bleeding, or itching.
Observation:
- A 44-year-old male presented with a right foot sole lesion initially diagnosed as benign eccrine poroma.
- Incomplete excision led to local recurrence, ulceration, bleeding, and inguinal lymphadenopathy within 5 months.
Findings:
- Histopathology confirmed malignant eccrine poroma with aggressive features, including lymphovascular and perineural invasion.
- No distant metastasis was detected.
- The patient showed a partial response to Docetaxel and Cisplatin chemotherapy.
Implications:
- This case highlights the potential for rapid malignant transformation or initial presentation as malignant eccrine poroma.
- Metastatic malignant eccrine poroma presents therapeutic challenges due to resistance to conventional treatments.
- Early and complete excision is crucial to prevent aggressive progression.