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Published on: June 18, 2021

[Primary antiphospholipid syndrome and cerebrovascular disturbances]

L A Kalashnikova

    Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
    |June 15, 2005
    PubMed

    Insights

    Primary antiphospholipid syndrome (PAS) often causes neurological issues, primarily ischemic cerebrovascular events like stroke and vascular dementia. Early detection and anticoagulant therapy are crucial for managing these serious neurological complications.

    Area of Science:

    • Neurology
    • Immunology
    • Vascular Medicine

    Context:

    • Primary antiphospholipid syndrome (PAS) is associated with a high incidence of neurological disorders.
    • Cerebrovascular disturbances are a common manifestation in PAS patients.

    Purpose:

    • To investigate the clinical characteristics and prevalence of cerebrovascular disorders in patients with primary antiphospholipid syndrome.

    Summary:

    • A study of 113 PAS patients revealed that cerebrovascular disorders were predominantly ischemic.
    • Key findings included stroke (33%), transient ischemic lesions (10%), combined events (57%), cerebral venous sinus thrombosis (3%), and vascular dementia (27%).
    • Other neurological symptoms observed were epileptic seizures, peripheral neuropathy, headache, chorea, and signs mimicking myasthenia, parkinsonism, multiple sclerosis, and psychosis.

    Impact:

    • Highlights the significant neurological burden of PAS, emphasizing ischemic cerebrovascular events.
    • Underscores the importance of detecting antiphospholipid antibodies in patients with unexplained neurological symptoms.
    • Informs secondary prophylaxis strategies, recommending anticoagulants and low-dose aspirin for PAS patients with cerebrovascular disease.

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