Assessing and using the multiple correlated components of the burden of disease in decision-making in health care
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R Clifton Bailey1, Monica J Y Lin, Henry Krakauer
1Division of Transplantation, HSB, HRSA, DHHS, 6507 Divine Street, McLean, VA 22101, USA. RCBailey@mac.com
Insights
This study introduces a new modeling approach to predict patient prognosis by analyzing mortality, morbidity, and resource use. This method supports better medical decision-making at both the bedside and policy levels.
Area of Science:
- Medical Decision-Making
- Health Informatics
- Biostatistics
Background:
- Effective medical decision-making requires accurate patient prognosis.
- Prognosis involves predicting the progression of mortality, morbidity, disability, psychological distress, and resource use over time.
Purpose of the Study:
- To develop and demonstrate a feasible method for analyzing and predicting the burden of disease.
- To support clinical and policy-level decision-making through improved prognostic modeling.
Main Methods:
- Utilized parametric representations and multivariate analysis for prognostic modeling.
- Calculated predicted individual and joint probabilities for various health outcomes and their combinations.
- Ensured predicted probabilities align with observed values.
Main Results:
- Demonstrated the feasibility of the developed modeling approach.
- Successfully predicted individual and joint probabilities of key prognostic measures.
- Validated the consistency of predicted probabilities with observed data.
Conclusions:
- The developed modeling approach is feasible for predicting disease burden.
- This method can effectively support medical decision-making at both clinical and policy levels.
- Accurate prognosis prediction is crucial for optimizing patient care and resource allocation.
Abstract:
In medical decision-making, we must (a) establish the patient's prognosis, and (b) identify the therapeutic strategy that will best improve that prognosis. The prognosis is the projected progression over time of the cumulative probability of (a) mortality, (b) morbidity, (c) disability, (d) psychological distress, and (e) resource use. Our modeling employs parametric representations and multivariate analysis to produce the predicted individual and joint probabilities of any range of each measure and of combinations of the measures. The predicted probabilities are consistent with their observed values. We have demonstrated, we believe, the feasibility of analyzing and predicting the burden of disease as a means to support decision-making at the bedside and the policy level.
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