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Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
Published on: April 7, 2023
[Effects of Icariin on ovariectomized osteoporotic rats]
Jia-rong Bao1, Ji-wen Yang, Shu-feng Li
1Life Science College, Northeast Agricultural University, Harbin 150030, China.
Objective:
To observe the effects of Icariin on ovariectomized osteoporotic rats.
Methods:
Female Wistar rats were ovariectomized and administered different dosage of Icariin and 17beta-estradiol for eight weeks. Bone mineral density (BMD), indexes of biomechanics and bone metabolism-associated biochemical markers were measured.
Results:
Icariin increased the BMD, maximum load and flexural rigidity in the osteoporotic rats. The activities of serum tartrate-resistant acid phosphatase (TRACP) and bone alkaline phosphatase (BALP) were decreased in the Icraiin-fed ovariectomized rats.
Conclusion:
Icariin 225mg/kg per day could increase the BMD and improve indexes of bone biomechanics in ovariectomized osteoporotic rats. It was effective in preventing bone loss induced by ovariectomy.
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