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Related Experiment Videos

Vancomycin-resistant enterococci: consequences for therapy and infection control.

E M Mascini1, M J M Bonten

  • 1Eijkman-Winkler Institute for Medical Microbiology, Infectious Diseases and Inflammation, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|June 15, 2005
PubMed
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Vancomycin-resistant enterococci (VRE) pose a growing threat in European hospitals. Infection control should focus on specific VRE strains to manage spread effectively and balance costs.

Area of Science:

  • Infectious Diseases
  • Hospital Epidemiology
  • Antimicrobial Resistance

Background:

  • Vancomycin-resistant enterococci (VRE) are emerging nosocomial pathogens in Europe.
  • Co-transmission of vancomycin resistance from VRE to MRSA highlights potential risks.
  • VRE endemicity prevention must balance strategy costs with low incidence.

Purpose of the Study:

  • To evaluate the feasibility and necessity of VRE infection control strategies in European hospitals.
  • To identify specific VRE strains responsible for hospital outbreaks.
  • To propose targeted VRE infection control measures.

Main Methods:

  • Review of VRE epidemiology in Europe.
  • Analysis of VRE transmission dynamics, including co-resistance and specific genes.

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  • Evaluation of current infection control practices and their limitations.

    • Main Results:

    • VRE outbreaks are increasing in Europe, though overall incidence remains low.
    • Specific VRE genogroups, characterized by co-resistance and the esp gene, are linked to outbreaks.
    • Identifying VRE carriers is challenging due to the lack of risk profiles.

    Conclusions:

    • VRE infection control programs should target patients colonized with specific, outbreak-associated VRE strains.
    • Surveillance and barrier precautions are recommended for contacts of patients with documented spread of these strains.
    • A targeted approach balances infection control needs with resource allocation.