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From Poisson distribution to interleukins

L Aarden1

  • 1Sanquin Research Department of Autoimmune Diseases, Amsterdam, the Netherlands. l.aarden@sanquin.nl

Scandinavian Journal of Immunology
|June 15, 2005
PubMed

Abstract In the mid-1970s, Ivan Lefkovits and co-workers introduced limiting dilution analysis of T and B cells as a method to quantify antigen-specific T and B cells. In this study, I describe how my co-operation with Ivan on the subject led not only to heated discussions on the validity of the approach but also to the identification of interleukin-2 as T-cell-derived factor, capable of replacing T-cell help required for the activation of B cells.

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