Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biogenic amines and thyrotoxicosis.

I Upadhyaya1, J K Agrawal, G P Dubey

  • 1Centre of Experimental Medicine and Surgery, Banaras Hindu University, Varanasi, India.

Acta Endocrinologica
|April 1, 1992
PubMed
Summary

Thyrotoxicosis alters biogenic amine metabolism, with elevated thyroid hormones (T3, T4) linked to increased 5-hydroxytryptamine, histamine, and glutamate. Treatment normalized these levels, suggesting amines as potential diagnostic markers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of carnitine on Hariana bull spermatozoa function after cryopreservation.

Cryo letters·2025
Same author

Fortification of semen extender with mifepristone improves the cryo-survival of cattle spermatozoa.

Cryo letters·2025
Same author

Effect of trans-cinnamaldehyde nanoemulsion wash on chicken embryo development in fertilized eggs.

Poultry science·2023
Same author

Erratum to "Trans-cinnamaldehyde nanoemulsion wash inactivates Salmonella Enteritidis on shelled eggs without affecting egg color" [Poultry Science, Volume 102, Issue 4, April 2023, 102523].

Poultry science·2023
Same author

Trans-cinnamaldehyde nanoemulsion wash inactivates Salmonella Enteritidis on shelled eggs without affecting egg color.

Poultry science·2023
Same author

Carvacrol attenuates Campylobacter jejuni colonization factors and proteome critical for persistence in the chicken gut.

Poultry science·2020

Area of Science:

  • Endocrinology and Neurochemistry
  • Investigates the intricate relationship between thyroid hormones and neurotransmitter metabolism.

Background:

  • Hyperthyroidism, or thyrotoxicosis, is characterized by elevated thyroid hormones (T3, T4).
  • Previous research suggests potential links between thyroid dysfunction and alterations in neurotransmitter levels.

Purpose of the Study:

  • To investigate circulating levels of thyroid hormones and key biogenic amines in hyperthyroid patients.
  • To explore the correlation between thyroid hormone levels and biogenic amine metabolism.
  • To assess the impact of treatment on these biochemical parameters.

Main Methods:

  • Measured serum T3, T4, gamma-aminobutyric acid (GABA), glutamate, 5-hydroxytryptamine (serotonin), histamine, monoamine oxidase (MAO), and histaminase in 45 hyperthyroid patients and 46 controls.
  • Analyzed biochemical markers before and after three months of hyperthyroid treatment.

Main Results:

  • Hyperthyroid patients exhibited elevated T3, T4, 5-hydroxytryptamine, histamine, and glutamate, with decreased GABA, MAO, and histaminase.
  • Treatment led to significant decreases in 5-hydroxytryptamine, histamine, and glutamate, alongside thyroid hormone normalization.
  • GABA, MAO, and histaminase levels increased post-treatment.
  • A positive correlation was observed between biogenic amine levels and thyroid hormone concentrations.

Conclusions:

  • Alterations in biogenic amine metabolism are associated with thyrotoxicosis.
  • These biogenic amine parameters may serve as valuable diagnostic and monitoring markers for hyperthyroid patients.

Related Experiment Videos