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Updated: Aug 17, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
The headache of SAH responds to sumatriptan
Jay H Rosenberg1, Stephen D Silberstein
1UCSD School of Medicine, La Jolla, CA and Jefferson Headache Center, Philadelphia, PA 19107, USA.
Abstract:
We report the first case of the headache of subarachnoid hemorrhage (SAH) possibly responding to a triptan. Recent evidence suggests that triptans block transmission from the trigeminal nerve to second-order neurons in the trigeminal nucleus caudalis; thus, any meningeal nociceptive process would be aborted. The triptans and ergots are not specific for migraine, but for any process that activates trigeminal fibers, including migraine, cluster headache, SAH, and meningitis. The failure to respond in the reported cases of meningitis may be due to sensitization.
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