Jove
Visualize
Contact Us

Related Experiment Videos

Getting RIP'd Stunts Your Growth.

Claire Ceni1, Philip A Barker

  • 1Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Quebec, Canada.

Neuron
|June 15, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

APP Genetic Deficiency Alters Intracellular Ca<sup>2+</sup> Homeostasis and Delays Axonal Degeneration in Dorsal Root Ganglion Sensory Neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2022
Same author

Mitochondrial Reactive Oxygen Species Mediate Activation of TRPV1 and Calcium Entry Following Peripheral Sensory Axotomy.

Frontiers in molecular neuroscience·2022
Same author

Cross-talk between GABAergic postsynapse and microglia regulate synapse loss after brain ischemia.

Science advances·2022
Same author

Precision and cost-effectiveness of bioindicators to estimate nutrient regimes on coral reefs.

Marine pollution bulletin·2021
Same author

NGF-Dependent and BDNF-Dependent DRG Sensory Neurons Deploy Distinct Degenerative Signaling Mechanisms.

eNeuro·2020
Same author

Nerve Growth Factor Signaling and Its Contribution to Pain.

Journal of pain research·2020
Same journal

Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses.

Neuron·2026
Same journal

Sparse component analysis: A method that uncovers separable computations within neural population activity.

Neuron·2026
Same journal

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens.

Neuron·2026
Same journal

TGF-β1-induced endothelial transcytosis drives blood-brain barrier leakage during aging.

Neuron·2026
Same journal

Image space opens up for visual neuroscience.

Neuron·2026
Same journal

Septal GLP-1 receptors control alcohol taking and seeking.

Neuron·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Myelin-associated glycoprotein (MAG) triggers growth inhibition by activating RhoA. This study reveals that MAG-induced intramembrane proteolysis (cleavage) of the p75 neurotrophin receptor (p75NTR) is essential for this process.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • The p75 neurotrophin receptor (p75NTR) is known to interact with the Nogo receptor (NgR) and LINGO-1.
  • This complex activates RhoA, a key regulator of cell growth, in response to myelin-based inhibitors like MAG.

Discussion:

  • This study uncovers a novel mechanism where MAG induces intramembrane proteolysis (RIP) of p75NTR.
  • The cleavage of p75NTR by MAG is demonstrated to be a critical step for initiating RhoA activation.

Key Insights:

  • MAG-induced cleavage of p75NTR is a prerequisite for RhoA activation.
  • This proteolysis event is essential for mediating the growth-inhibitory effects of MAG.

Outlook:

  • Further research can explore therapeutic strategies targeting p75NTR cleavage to promote neural regeneration.

Related Experiment Videos

  • Understanding this pathway could offer new insights into treating conditions associated with myelin damage.