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Cataract progression after intravitreal triamcinolone injection.
Osman Cekiç1, Stanley Chang, Joseph J Tseng
1Department of Ophthalmology, College of Surgeons and Physicians of Columbia University, Harkness Eye Institute, 635 West 165th Street, New York, NY 10032, USA. oc2106@columbia.edu
American Journal of Ophthalmology
|June 15, 2005
Summary
Intravitreal triamcinolone injections can accelerate cataract progression. Single injections led to posterior subcapsular cataracts, while multiple injections caused all-layer cataract development.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Intravitreal triamcinolone acetonide is used for various ocular conditions.
- Cataract formation is a potential side effect of corticosteroid use.
Purpose of the Study:
- To evaluate the impact of intravitreal triamcinolone injections on cataract progression.
- To compare cataract development in injected eyes versus control eyes.
Main Methods:
- Retrospective case-control study involving 42 phakic eyes from 37 patients.
- Eyes received one, two, or three intravitreal triamcinolone injections; fellow eyes served as controls.
- Lens status, visual acuity, and refractive errors were monitored over a mean follow-up of 12-14 months.
Main Results:
- Single injections significantly increased posterior subcapsular cataracts and altered refractive error compared to controls.
- Multiple injections led to significant progression in corticonuclear and posterior subcapsular cataracts, and refractive error.
- Visual acuity decreased after multiple injections, with 11 study eyes and 2 control eyes requiring cataract extraction.
Conclusions:
- Single intravitreal triamcinolone injections are associated with posterior subcapsular cataract development.
- Multiple intravitreal triamcinolone injections can lead to comprehensive cataract progression affecting all lens layers.