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Related Experiment Videos

Electrophysiological changes in lipaemia retinalis.

Chao-Kung Lu1, Shih-Jen Chen, Dau-Ming Niu

  • 1Department of Ophthalmology, Taipei Veterans General Hospital, #201 Section 2 Shih-Pai Road, Taipei 112, Taiwan.

American Journal of Ophthalmology
|June 15, 2005
PubMed
Summary

Lipaemia retinalis, a condition causing milky retinal vessels, can impair electroretinogram responses in diabetic patients. Prompt lipid correction rapidly reverses these electrophysiologic deficits, preserving vision.

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Area of Science:

  • Ophthalmology
  • Diabetology
  • Clinical Electrophysiology

Background:

  • Lipaemia retinalis is a rare condition characterized by milky-appearing retinal vessels, often associated with severe hypertriglyceridemia or hypercholesterolemia.
  • Diabetes mellitus is a common comorbidity that can exacerbate lipid metabolism disorders.

Observation:

  • An 11-year-old girl with diabetes presented with lipaemia retinalis, exhibiting milky discoloration of retinal vessels.
  • Funduscopic examination revealed significant hyperglycemia and elevated triglyceride and cholesterol levels.
  • Despite unaffected visual acuity, electroretinograms (ERG) demonstrated reduced a- and b-wave amplitudes in both cone and rod responses.

Findings:

  • The lipaemia retinalis resolved rapidly within one week following insulin therapy and dietary modifications to control blood sugar and lipids.

Related Experiment Videos

  • The electroretinogram abnormalities, including decreased cone and rod responses, showed complete reversal concurrently with the resolution of lipaemia retinalis.
  • This case represents the first report of reversible electroretinogram deficits in lipaemia retinalis.

    • Implications:

    • This study highlights that severe hyperlipidemia can transiently impair retinal function, as evidenced by ERG changes.
    • The rapid reversibility of ERG deficits upon lipid correction suggests a functional rather than structural retinal damage mechanism.
    • Early detection and management of hyperlipidemia in diabetic patients are crucial to prevent potential long-term visual complications.