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Updated: Aug 17, 2026

Calcium Imaging in Mouse Superior Colliculus
Published on: April 21, 2023
Salicylate blocks L-type calcium channels in rat inferior colliculus neurons
Yanxing Liu1, Xuepei Li, Changsheng Ma
1Department of Neurobiology, Hebei Medical University, No. 361 Zhongshan East Road, Changan District, Shijiazhuang 050017, PR China. liuyanxing75@sohu.com
Abstract:
To investigate the effects of the tinnitus inducer sodium salicylate on L-type voltage-gated calcium channels, we studied freshly dissociated inferior colliculus neurons of rats by the whole-cell voltage clamp method. Salicylate's blocking of L-type calcium channels was concentration dependent, and the IC(50) value of salicylate was estimated to be 1.99 mM. An amount of 1 mM salicylate significantly shifted the steady-state inactivation curve of L-type calcium channels about 9 mV in the hyperpolarizing direction and significantly delayed calcium channel recovery. Our results suggest that salicylate's blocking of L-type calcium channels may contribute to salicylate-induced tinnitus by decreasing GABA release in the inferior colliculus.
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