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Updated: Aug 17, 2026
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
BCG modulation of anaphylactic antibody response, airway inflammation and lung hyperreactivity in genetically
Myrthes Toledo Barros1, Milena Marques Pagliarelli Acencio, Maria Lúcia Bueno Garcia
1Division of Clinical Immunology and Allergy, Heart Institute (InCor), Division of General Internal Medicine, Department of Medicine, University São Paulo, Av. Dr. Arnaldo, 455, Cerqueira César, 01246-903, São Paulo, Brazil. myrtb@uol.com.br
Abstract:
The effect of Bacillus Calmette-Guérin (BCG) treatment in allergic pulmonary reaction was studied in mice genetically selected accordingly to a High (H-IVA) or Low (L-IVA) antibody responsiveness. Mice were immunized with ovalbumin (OVA) or OVA plus BCG. Two days after nasal antigenic challenge, seric IgE and IgG1 anti-OVA, eosinophils in pulmonary tissue, inflammatory cells in bronchoalveolar lavage and the compliance and conductance of respiratory system were evaluated. H-IVA mice were found more susceptible than L-IVA, and BCG was able to inhibit simultaneously the production of IgE, the bronchopulmonary inflammation and bronchial hyperresponsiveness in these genetically selected mice.
