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[Methods for preserving bone marrow for autologous transplantation]
F L da Costa1, P Pimentel, A Tavares
1Unidade de Transplantação de Medula Ossea (UTMO) do Hospital de Santa Maria, Lisboa.
Acta Medica Portuguesa
|February 1, 1992
Summary
Autologous Bone Marrow Transplantation (ABMT) requires preserving patient marrow. This review covers bone marrow preservation methods, focusing on cryopreservation for extended storage.
Area of Science:
- Hematology
- Oncology
- Cell Biology
Context:
- Autologous Bone Marrow Transplantation (ABMT) involves harvesting and reinfusing a patient's own bone marrow.
- High-dose radio-chemotherapy necessitates effective bone marrow preservation between collection and reinfusion.
- The duration of marrow preservation is critical and depends on the specific therapeutic protocol.
Purpose:
- To review current methods for bone marrow preservation.
- To emphasize the importance and techniques of cryopreservation for long-term marrow storage.
- To describe the specific cryopreservation method used at the Hospital de Santa Maria Bone Marrow Transplant Unit.
Summary:
- Bone marrow can maintain hematopoietic potential for short periods without freezing.
- Longer-term preservation requires cryopreservation techniques.
- The study details various marrow preservation strategies and the Hospital de Santa Maria's cryopreservation protocol.
Impact:
- Ensures the viability and hematopoietic potential of autologous bone marrow for transplantation.
- Facilitates extended therapeutic windows for high-dose radio-chemotherapy regimens.
- Provides insights into established cryopreservation protocols for clinical application in ABMT.