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6-Aryl-4-methylsulfanyl-2H-pyran-2-one-3-carbonitriles as PPAR-gamma activators
Ashoke Sharon1, Ramendra Pratap, Rit Vatsyayan
1Molecular and Structural Biology Division, Central Drug Research Institute, Lucknow 226001, India.
Abstract:
Various 6-aryl-3-cyano/methoxycarbonyl-4-methylsulfanyl-2H-pyran-2-ones have been synthesized as a potential substitute of 2,4-thiazolidinedione head group to express potent PPAR-gamma transactivation response. Some of the screened compounds have shown promising PPAR-gamma agonistic activity.
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