Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Aging and free radicals].

C Manso1

  • 1Instituto de Química Fisiológica, Faculdade de Medicina, Lisboa.

Acta Medica Portuguesa
|February 1, 1992
PubMed
Summary
This summary is machine-generated.

Aging theories are explored, highlighting cellular damage from oxygen radicals and glucose-induced Maillard reactions as key contributors. While multiple factors influence aging, a comprehensive explanation remains elusive.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Midazolam prescription as a trigger for potential deceased donor identification outside the ICU: a prospective feasibility study.

BMC palliative care·2026
Same author

Clinical Complete Response and Organ Preservation Strategies in Rectal Cancer: A Real-World Single-Center Experience Clinical Complete Response and Organ Preservation in Rectal Cancer.

Cancers·2026
Same author

Incidence and Survival of IDH-Wildtype Glioblastoma and IDH-Mutant Astrocytoma by Treatment and Sex: A Regional Study in Spain (2011-2021).

Medical sciences (Basel, Switzerland)·2025
Same author

Probable chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids syndrome: management with corticosteroids and intravenous immunoglobulin-a case report.

Journal of medical case reports·2025
Same author

Fanconi-like anemia related to a FANCM mutation.

European journal of medical genetics·2021
Same author

[Alcohol and resistance to infections].

Acta medica portuguesa·2001

Area of Science:

  • Gerontology
  • Cellular Biology
  • Biochemistry

Context:

  • Aging is a complex biological process with multiple contributing factors.
  • Existing theories on aging offer partial explanations but lack comprehensive scope.
  • Cellular metabolism and molecular damage are central to aging research.

Purpose:

  • To review and synthesize current theories of aging.
  • To emphasize the roles of oxygen radicals and glucose metabolism in aging.
  • To discuss the multifactorial nature of senescence.

Summary:

  • Multiple aging theories exist, each providing valuable insights but failing to fully account for the phenomenon.
  • Cellular respiration generates oxygen radicals, leading to cumulative microlesions that drive aging.

Related Experiment Videos

  • Glucose contributes to aging via the formation of early and late Maillard reaction compounds.
  • Other contributing factors to the aging process are also considered.

    • Impact:

    • Provides a consolidated overview of aging theories for researchers.
    • Highlights key molecular mechanisms, including oxidative stress and glycation, in aging.
    • Underscores the need for integrated approaches to understand and potentially mitigate aging.