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Published on: January 28, 2020

Relations of plasma high-sensitivity C-reactive protein to various cardiovascular risk factors

So Yeon Ryu1, Young Sun Lee, Jong Park

  • 1Department of Preventive Medicine, Chosun University College of Medicine, Korea. canrsy@chosun.ac.kr

Journal of Korean Medical Science
|June 15, 2005
PubMed

Insights

High-sensitivity C-reactive protein (hsCRP) correlates with cardiovascular risk factors like age, blood pressure, and body mass index in adults over 50. These findings suggest hsCRP may indicate preclinical cardiovascular disease.

Area of Science:

  • Biochemistry
  • Cardiology
  • Epidemiology

Background:

  • Cardiovascular disease remains a leading cause of mortality worldwide.
  • Biomarkers for early detection of cardiovascular disease are crucial for timely intervention.
  • High-sensitivity C-reactive protein (hsCRP) is an inflammatory marker associated with cardiovascular risk.

Purpose of the Study:

  • To investigate the association between plasma hsCRP levels and various cardiovascular risk factors.
  • To identify independent predictors of hsCRP levels in an adult population.

Main Methods:

  • Cross-sectional survey of 202 Korean adults over 50 years old.
  • Plasma hsCRP measured by immunoturbidimetry.
  • Statistical analysis including stepwise multivariate regression.

Main Results:

  • Significant associations found between hsCRP and age, white blood cell count, blood glucose, diastolic blood pressure, HDL-cholesterol, body mass index, and smoking status.
  • Independent correlates of hsCRP were white blood cell count, age, blood glucose, smoking status, and body mass index.
  • Mean plasma hsCRP level was 1.9 +/- 3.0 mg/dL.

Conclusions:

  • Plasma hsCRP levels are associated with multiple cardiovascular risk factors in adults over 50.
  • These findings support the hypothesis that hsCRP may serve as a marker for preclinical cardiovascular disease.
  • Prospective studies are needed to confirm the association between hsCRP and future cardiac events.

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