Strategies for targeting protein-protein interactions with synthetic agents
1Yale University, New Haven, CT, USA.
Angewandte Chemie (International Ed. in English)
|June 15, 2005
Abstract:
The development of small-molecule modulators of protein-protein interactions is a formidable goal, albeit one that possesses significant potential for the discovery of novel therapeutics. Despite the daunting challenges, a variety of examples exists for the inhibition of two large protein partners with low-molecular-weight ligands. This review discusses the strategies for targeting protein-protein interactions and the state of the art in the rational design of molecules that mimic the structures and functions of their natural targets.
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