Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Template-synthesized DNA nanotubes.

Shifeng Hou1, Jiahai Wang, Charles R Martin

  • 1Department of Chemistry and Center for Research at the Bio/Nano Interface, University of Florida, Gainesville, Florida 32611-7200, USA.

Journal of the American Chemical Society
|June 16, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-sensitivity pan-cancer AI assessment of lymph node metastasis via uncertainty quantification.

NPJ digital medicine·2026
Same author

Construction of bilayer asymmetric humidity-regulating packaging using 2-hydroxypropyl trimethyl ammonium chloride chitosan for enhanced strawberry preservation.

Carbohydrate polymers·2026
Same author

Multiscale Engineering of PEO Electrolytes for High-Voltage and Ultrastable Solid-State Lithium Batteries With Exceptional Room-Temperature Performance.

Angewandte Chemie (International ed. in English)·2026
Same author

Assessing the inhibition efficacy of clinical drugs against the main proteases of SARS-CoV-2 variants and other coronaviruses.

Quantitative biology (Beijing, China)·2026
Same author

Ultrastable and High-Rate Sodium Storage Enabled by High-Entropy Doping in HE-Fe<sub>3</sub>Se<sub>4</sub>/Se/MXene Composites.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

The Progress of Black Phosphorus in the Field of Sensors.

Critical reviews in analytical chemistry·2025

Researchers developed a new method to create DNA nanotubes using a template synthesis approach. These novel DNA nanostructures offer potential applications in gene delivery and separations.

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biotechnology

Background:

  • DNA-functionalized nanotubes are of interest for applications like gene delivery and separations.
  • Current methods attach DNA to nanotubes made of other materials, typically carbon.
  • There is a need for nanotubes composed primarily of DNA.

Purpose of the Study:

  • To describe a template synthesis method for preparing DNA nanotubes.
  • To explore the potential of DNA-based nanostructures.

Main Methods:

  • Utilized a layer-by-layer alpha,omega-diorganophosphonate (alpha,omega-DOP) Zr(IV) chemistry.
  • Employed an alumina template membrane for nanotube synthesis.
  • Constructed DNA nanotubes with an outer Zr(IV) layer and an inner core of double-stranded DNA.

Related Experiment Videos

Main Results:

  • Successfully synthesized DNA nanotubes using the described template method.
  • The DNA nanotubes possess an outer structural layer and an inner DNA core.
  • The DNA component can be released by melting the DNA duplexes.

Conclusions:

  • A novel method for creating DNA nanotubes has been established.
  • These DNA nanotubes offer a new platform for various applications.
  • The ability to release DNA provides functional versatility.