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Updated: Feb 8, 2026

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Published on: June 20, 2019

Bilayers and interdigitation in block copolymer vesicles.

Giuseppe Battaglia¹, Anthony J Ryan

¹Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, U.K.

Journal of the American Chemical Society

|June 16, 2005

Summary

This summary is machine-generated.

Amphiphilic block copolyethers form membranes with thicknesses of 2.4–7.5 nm. Hydrophobic block length dictates membrane thickness, aligning with strong segregation theory for polymer melts.

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Published on: October 10, 2016

Lipid Bilayer Vesicle Generation Using Microfluidic Jetting

Lipid Bilayer Vesicle Generation Using Microfluidic Jetting

Published on: February 21, 2014

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Last Updated: Feb 8, 2026

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Published on: June 20, 2019

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

Lipid Bilayer Vesicle Generation Using Microfluidic Jetting

Lipid Bilayer Vesicle Generation Using Microfluidic Jetting

Published on: February 21, 2014

Area of Science:

Polymer Science
Materials Science
Supramolecular Chemistry

Background:

Amphiphilic block copolyethers self-assemble into various nanostructures.
Understanding the morphology and chain conformation in these self-assembled systems is crucial for designing advanced materials.

Purpose of the Study:

To investigate the membrane thickness and hydrophobic chain conformation in self-assembled vesicles formed by amphiphilic block copolyethers.
To compare experimental findings with theoretical predictions, specifically the strong segregation theory.

Main Methods:

Small-angle X-ray scattering (SAXS) to determine membrane structure and thickness.
Electron microscopy (EM) to visualize vesicular morphology.
Analysis of membrane thickness scaling with hydrophobic block length.

Main Results:

Vesicular morphology was confirmed for both diblock and triblock copolyethers.
Membrane thicknesses ranged from 2.4 to 7.5 nm.
Observed scaling of membrane thickness with hydrophobic block length agreed with strong segregation theory.

Conclusions:

Hydrophobic chains within the vesicle membranes adopt a mixed and stretched conformation.
This conformation differs from previous observations of unperturbed Gaussian dimensions and bilayer structures.