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Updated: Aug 17, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
Published on: January 29, 2014
Severe hemolytic anemia due to auto anti-N
C C Immel1, M McPherson, S N Hay
1Transfusion Medicine Service, UNC Hospitals, 1021 East Wing, 101 Manning Drive, Chapel Hill, NC 27514, USA.
Abstract:
Auto anti-N is infrequently encountered and, in most reported cases, does not cause clinical hemolysis. This case reports an auto anti-N associated with severe hemolytic anemia (Hb=2.7 g/dL) in a 6-year-old Caucasian girl with a history of vomiting, fever, and abdominal pain. Upon admission, she was found to have a metabolic acidosis, secondary to her severe anemia, with abnormal liver function tests. As in three other case reports, the autoimmune hemolytic anemia resolved, with disappearance of the auto anti-N, after corticosteroid therapy.
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