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Updated: Aug 17, 2026

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay
Published on: September 10, 2018
Pharmacokinetic/pharmacodynamic evaluation of anti-infective agents
Edgar L Schuck1, Hartmut Derendorf
1Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA. eschuck@ufl.edu
Abstract:
Pharmacokinetic/pharmacodynamic modeling has become an extremely important tool in evaluating and optimizing anti-infective therapy. By systematically linking the pharmacokinetic and pharmacodynamic properties of the anti-infective agent, it is possible to make educated decisions about the correct drug to be used, correct dosing regimen and to estimate the probability of success with the selected dose regimen. This article gives an overview of the current pharmacokinetic/pharmacodynamic approaches for anti-infective agents and discusses their use in optimizing drug therapy.
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