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Cardiovascular calcification in Hispanic Americans (HA) with chronic kidney disease (CKD) due to type 2 diabetes

Wajeh Y Qunibi1, Fadi Abouzahr, Mohammad R Mizani

  • 1Department of Medicine, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas 78229-3900, USA. qunibi@uthscsa.edu

Kidney International
|June 16, 2005
PubMed

Insights

Cardiovascular calcification (CVC) is common in patients with chronic kidney disease (CKD) not on dialysis. Advanced CKD significantly increases the prevalence and severity of coronary and peripheral artery calcification (CAC and PAC).

Area of Science:

  • Nephrology
  • Cardiology
  • Radiology

Background:

  • Cardiovascular calcification (CVC) is prevalent in end-stage renal disease patients on dialysis.
  • CVC prevalence and severity are less understood in non-dialysis chronic kidney disease (CKD) patients.
  • Diabetic patients with CKD are a key population to study for vascular calcification.

Purpose of the Study:

  • To investigate the prevalence and severity of CVC in non-dialysis diabetic patients with varying stages of CKD.
  • To assess the association between renal function and vascular calcification burden in predialysis CKD patients.

Main Methods:

  • Fifty-eight non-dialyzed diabetic patients with CKD were enrolled.
  • Patients were divided into early (CKD stages 1-2) and advanced (CKD stages 4-5) groups.
  • Coronary artery calcification (CAC) was measured using ultrafast spiral computed tomography; peripheral artery calcification (PAC) was evaluated using plain x-ray.

Main Results:

  • Prevalence of CAC and PAC was significantly higher in the advanced CKD group (73% vs. 38% and 85% vs. 35%, respectively).
  • Median CAC scores were 18-fold greater in the advanced CKD group.
  • A strong association was found between reduced renal function and increased CAC volume.

Conclusions:

  • Coronary and peripheral artery calcification are common and severe in diabetic patients with predialysis CKD.
  • Lower renal function levels correlate with a higher burden of vascular calcification in these patients.
  • These findings highlight the importance of monitoring vascular calcification in non-dialysis CKD patients.
Abstract

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