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Development and application of rodent models for type 2 diabetes
1The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, PR China.
Diabetes, Obesity & Metabolism
|June 16, 2005
Summary
This review details common rodent models for type 2 diabetes research, crucial for understanding this complex disease and developing new treatments. These models aid in studying insulin resistance and beta-cell dysfunction.
Area of Science:
- Endocrinology
- Diabetology
- Animal Models
Background:
- Global rise in adult diabetes presents a significant public health challenge.
- Type 2 diabetes, characterized by insulin resistance and beta-cell dysfunction, affects millions, particularly in the USA.
- Effective experimental models are vital for elucidating disease mechanisms and therapeutic strategies.
Purpose of the Study:
- To review commonly used rodent models for type 2 diabetes research.
- To discuss models developed spontaneously, via genetic engineering, or artificial manipulation.
- To highlight the importance of these models in understanding diabetes pathogenesis.
Main Methods:
- Review of existing literature on rodent diabetic models.
- Categorization of models based on development (spontaneous, genetic engineering, artificial manipulation).
- Inclusion of other animal models for comparative context.
Main Results:
- Rodent models are extensively studied due to practical advantages like short generation times and genetic traits.
- Various spontaneous, genetically engineered, and artificially induced rodent models are available.
- Other species like Psammomys obesus and rhesus monkeys are also utilized.
Conclusions:
- Rodent models are indispensable tools for advancing type 2 diabetes research.
- The selection of appropriate models is critical for studying molecular basis, vascular/neural complications, and treatment efficacy.
- Continued research utilizing diverse animal models will enhance our understanding of type 2 diabetes.