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Published on: September 24, 2021
Aspergillus pacemaker endocarditis presenting as pulmonary embolism
A Mateos-Colino1, R Golpe, A González-Rodríguez
1Respiratory Section (Internal Medicine Service), Hospital de Monforte de Lemos, Lugo, Spain. alfonsomateos10@hotmail.com
Abstract:
Pacemaker endocarditis (PME) is a rare but severe complication of endocardial pacemaker implantation. Fungal PME is extremely uncommon. The case of a 66-year-old female patient who was diagnosed as having a pulmonary embolus based upon the patient's clinical presentation and computed tomography angiography findings is presented. Transthoracic echocardiography demonstrated a huge vegetation attached to the pacemaker wire. The pacemaker system was removed surgically during cardiovascular bypass. The vegetation was cultured, the results of which were positive for Aspergillus spp. No risk factors for Aspergillus infection were found in the patient. She was treated with liposomal amphotericin B for 3 weeks, followed by itraconazole for 40 weeks. At 1 year later, the patient remains asymptomatic.
Insights
This case study highlights an extremely rare instance of fungal pacemaker endocarditis (PME) caused by Aspergillus in a 66-year-old female. Prompt surgical removal and antifungal treatment led to a successful recovery.
Area of Science:
- Cardiology
- Infectious Diseases
- Medical Device Complications
Background:
- Pacemaker endocarditis (PME) is a serious complication of pacemaker implantation.
- Fungal PME is exceptionally rare, posing diagnostic and therapeutic challenges.
Observation:
- A 66-year-old female presented with symptoms suggestive of pulmonary embolism.
- Computed tomography angiography and transthoracic echocardiography revealed a large vegetation on the pacemaker wire.
Findings:
- Surgical removal of the pacemaker system was performed.
- Culture of the vegetation identified Aspergillus spp. as the causative agent.
- The patient had no identifiable risk factors for Aspergillus infection.
Implications:
- This case underscores the importance of considering rare fungal infections in PME, even without typical risk factors.
- Successful management involves a multidisciplinary approach including surgery and prolonged antifungal therapy.
- Early diagnosis and intervention are crucial for favorable outcomes in fungal PME.
Related Concept Videos
Endocarditis I: Introduction
Endocarditis II: Clinical Features of Infective Endocarditis
Pulmonary Embolism I: Introduction
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Pulmonary Embolism III: Nursing Management
Pulmonary Embolism I: Introduction

