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Related Experiment Videos

Hemispheric differences in hemodynamics elicited by auditory oddball stimuli.

Michael C Stevens1, Vince D Calhoun, Kent A Kiehl

  • 1Olin Neuropsychiatry Research Center, The Institute of Living, Hartford, CT 06106, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.

Neuroimage
|June 16, 2005
PubMed
Summary

The right brain hemisphere shows greater activity than the left during attention tasks involving novel or target stimuli. This functional asymmetry was consistent across participants, regardless of age or gender.

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Area of Science:

  • Neuroscience
  • Cognitive Psychology

Background:

  • Neuroimaging suggests right hemisphere specialization for attention.
  • Functional asymmetry in hemodynamic response magnitude for attention has been underexplored.

Purpose of the Study:

  • To investigate hemispheric differences in hemodynamic response amplitude during an auditory oddball task.
  • To test the hypothesis of greater right-hemisphere activation for salient stimuli (targets and novel stimuli).

Main Methods:

  • Utilized a novel voxel-based comparison method for event-related fMRI data.
  • Analyzed hemodynamic response amplitude to target, novel, and standard stimuli in 100 healthy adults.
  • Examined auditory oddball task performance.

Main Results:

Related Experiment Videos

  • Greater right frontal, temporal, and parietal lobe activity observed for target detection and novelty processing.
  • Hemodynamic response asymmetry did not vary with participant age or gender.
  • Confirmed right hemisphere engagement in processing salient stimuli.

Conclusions:

  • The right hemisphere is differentially engaged in processing salient stimuli.
  • The study validates a new voxel-based laterality analysis technique for fMRI data.