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Updated: Aug 9, 2026

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors
Published on: September 13, 2013
Identification of G-protein-coupled receptors involved in inflammatory disease by genetic association studies
Roy Pettipher1, Jon Mangion, Michael G Hunter
1Department of Drug and Target Discovery, Oxagen Ltd, 91 Milton Park, Abingdon, Oxon OX14 4RY, UK. r.pettipher@oxagen.co.uk
Abstract:
G-protein-coupled receptors are not only highly tractable drug targets but also attractive candidates for genetic association studies because they are more polymorphic than most other classes of gene and these polymorphisms frequently lead to functional changes in the levels of expression or biological activity that can predispose to common diseases. A large-scale study to identify functional variants in G-protein-coupled receptors associated with inflammatory diseases has highlighted a spectrum of novel biological insights that range from identifying the involvement of orphan receptors in certain diseases through to highlighting new therapeutic indications for existing drugs.
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