Pulmonary meningioma. Report of a case with electron microscopic and immunohistochemical findings

Related Experiment Video

Updated: Sep 30, 2026

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
06:32

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

P G Robinson1

  • 1Department of Pathology, University of Miami School of Medicine, Florida 33101.

American Journal of Clinical Pathology
|June 1, 1992
PubMed

Insights

A rare pulmonary meningioma was surgically removed from a patient. Immunohistochemical and electron microscopic studies confirmed its similarity to cranial meningiomas, suggesting a potential common origin.

Area of Science:

  • Pulmonary pathology
  • Neurosurgery
  • Oncology

Background:

  • Meningiomas are typically found in the brain or spinal cord.
  • Pulmonary meningiomas are exceptionally rare primary lung tumors.

Observation:

  • A 55-year-old woman presented with a resected pulmonary meningioma.
  • Post-surgical follow-up revealed no evidence of cranial meningioma for 3 years.

Findings:

  • Immunohistochemical and electron microscopic analyses showed the pulmonary tumor was indistinguishable from cranial meningiomas.
  • Tumor markers and cellular structures were consistent with meningothelial differentiation.

Implications:

  • This case supports the hypothesis of a potential common origin for pulmonary and cranial meningiomas.
  • Further research into the embryological or metastatic pathways of meningiomas is warranted.
  • Highlights the importance of considering rare diagnoses in pulmonary oncology.

More Related Videos

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Related Concept Videos

Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...