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Published on: March 7, 2025
Growth in children with Helicobacter pylori infection and dyspepsia
M R Sood1, S Joshi, A K Akobeng
1Division of Pediatric Gastroenterology and Nutrition, Medical College of Wisconsin, Milwaukee, WI 53226, USA. MSood@mail.mcw.edu
Insights
Children with Helicobacter pylori infection and dyspepsia were shorter and lighter. However, these anthropometric differences were linked to socioeconomic and ethnic factors, not the infection itself.
Area of Science:
- Pediatric Gastroenterology
- Infectious Diseases
- Public Health
Background:
- Dyspeptic symptoms are common in children.
- Helicobacter pylori (H. pylori) infection is a known cause of gastrointestinal issues.
- Socioeconomic factors can influence child health and development.
Purpose of the Study:
- To compare anthropometric measurements (height, weight, BMI) in children with dyspepsia and H. pylori infection versus those with dyspepsia alone.
- To investigate the role of socioeconomic deprivation in these comparisons.
Main Methods:
- Retrospective chart review of 257 children.
- H. pylori infection diagnosed via 13C urea breath test.
- Anthropometric data analyzed using UK normative data and Index of Multiple Deprivation (IMD) scores.
Main Results:
- Children with H. pylori infection had significantly higher deprivation scores.
- H. pylori positive children were shorter and lighter (lower SD scores).
- Anthropometric differences were not significant after adjusting for socioeconomic and ethnic factors.
Conclusions:
- Observed differences in height and weight in children with H. pylori and dyspepsia are likely attributable to socioeconomic and ethnic factors.
- H. pylori infection itself may not be the primary driver of these anthropometric variations.
Aims:
To compare the height, weight, and body mass index (BMI) of children presenting with dyspeptic symptoms and Helicobacter pylori infection, to those with dyspepsia but without the infection.
Methods:
A retrospective chart review of 257 children was performed. 13C urea breath test was performed to detect H pylori infection; weight and height were recorded and BMI was calculated. Weight, height, and BMI SD scores were determined using the 1990 UK normative data. The Index of Multiple Deprivation 2004 (IMD 2004) scores, which measure deprivation at small area level, were calculated from the patients' postcodes.
Results:
Ninety seven of the 257 children were H pylori positive. The mean age at diagnosis and presenting symptoms of H pylori positive and negative patients were similar. The mean IMD 2004 scores for children with H pylori infection were significantly higher compared to H pylori negative patients, suggesting that children with the infection came from relatively more deprived areas. The mean weight and height SD score were significantly lower for children with H pylori infection compared to those without. However, this difference was no longer significant after adjusting for socioeconomic deprivation and ethnic differences between the groups.
Conclusion:
Children with dyspepsia and H pylori infection were shorter and lighter than patients with similar symptoms but no infection. The differences in anthropometry may be due to socioeconomic and ethnic factors rather than H pylori infection.
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