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Published on: October 25, 2018
Anti-MuSK myasthenia gravis presenting with purely ocular findings
James B Caress1, Christopher H Hunt, Sat Dev Batish
1Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. jcaress@wfubmc.edu
Background:
Antibodies to a muscle-specific receptor tyrosine kinase (MuSK) have been found in approximately 40% of patients with generalized myasthenia gravis who are seronegative for the antiacetylcholine receptor antibody. Many of the patients with anti-MuSK antibodies have prominent oculobulbar symptoms or weakness of the neck and respiratory muscles, but patients with ocular myasthenia have not been described.
Objective:
To report a case of ocular myasthenia due to anti-MuSK antibodies.
Patient:
A young woman with ocular myasthenia and antibodies to MuSK.
Results:
Anti-MuSK antibody was detected by radioimmunoassay using highly purified MuSK recombinant antigen.
Conclusion:
Ocular myasthenia gravis is a presentation of the anti-MuSK antibody syndrome.
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