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Nationwide antibiogram analysis using NCCLS M39-A guidelines.

Antonia Zapantis1, Melinda K Lacy, Rebecca T Horvat

  • 1Nova Southeastern University College of Pharmacy, 3200 South University Drive, Fort Lauderdale, FL 33308, USA. zapantis@nsu.nova.edu

Journal of Clinical Microbiology
|June 16, 2005
PubMed
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Standardizing antibiogram (ABGM) preparation is crucial. This study found many US antibiograms did not meet guidelines, highlighting needs for improved reporting of antimicrobial susceptibility data.

Area of Science:

  • Clinical Microbiology
  • Infectious Diseases
  • Antimicrobial Stewardship

Background:

  • Standardization in antibiogram (ABGM) preparation has been lacking.
  • Antibiograms provide essential antimicrobial susceptibility data for clinical decision-making.

Purpose of the Study:

  • To analyze current antibiogram preparation and reporting practices in the United States.
  • To identify areas for improvement based on the NCCLS M39-A guidelines.
  • To evaluate the quality of reported antimicrobial susceptibility data.

Main Methods:

  • Collected 209 antibiograms from 149 institutions across the US.
  • Analyzed antibiograms using elements from the NCCLS M39-A guidelines.
  • Evaluated seven quality indicators for atypical or inappropriate susceptibility data.

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Main Results:

  • 85% compliance with 5 out of 10 analyzed M39-A elements.
  • Commonly unmet elements: annual analysis, duplicate isolate notation, exclusion of <10 isolates.
  • Identified unexpected results: <100% vancomycin susceptibility for S. aureus (7%), inconsistent beta-lactam susceptibility for S. aureus (24%), <100% imipenem susceptibility for E. coli (20%), >0% ampicillin susceptibility for K. pneumoniae (37%).

Conclusions:

  • Significant gaps exist in antibiogram preparation and reporting standardization.
  • Thorough review by infectious disease specialists, clinical microbiologists, and infection control personnel is recommended before distribution.
  • Improvements in adherence to guidelines are needed to ensure accurate antimicrobial susceptibility data.