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Glucose malabsorption associated with rapid intestinal transit.

J H Sellin¹, R Hart

¹Division of Gastroenterology, The University of Texas Medical School, Houston.

The American Journal of Gastroenterology

|May 1, 1992

Summary

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Rapid intestinal transit may cause chronic diarrhea in some patients. A combined glucose-hydrogen breath test and nuclear transit scan can identify this subgroup, improving diagnosis of bacterial overgrowth.

Area of Science:

Gastroenterology
Diagnostic Imaging
Microbiology

Background:

Chronic diarrhea affects numerous patients, with abnormal intestinal transit and bacterial overgrowth being potential contributing factors.
Accurate diagnosis of chronic diarrhea requires understanding the interplay between gut motility and microbial activity.

Observation:

A study investigated 25 chronic diarrhea patients using a combined glucose-hydrogen breath test (GHBT) and nuclear transit scan.
Eight patients presented with rapid orocecal transit (<30 min) and a positive GHBT (>20 ppm H2 increase).

Findings:

These eight patients lacked anatomical abnormalities for small bowel bacterial overgrowth.
The findings suggest colonic bacterial metabolism of carbohydrates due to glucose malabsorption secondary to rapid transit.

Related Experiment Videos

Autonomic dysfunction was observed in these patients, often linked to systemic diseases.

Implications:

A subset of chronic diarrhea cases may be attributed to rapid intestinal transit.
The combined GHBT-nuclear transit scan is effective in identifying individuals with rapid transit and associated glucose malabsorption.
This combined approach enhances the diagnostic accuracy of hydrogen breath tests for bacterial overgrowth.