Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reference values for long echo time MR spectroscopy in healthy adults.

Yair Safriel1, Marlyanne Pol-Rodriguez, Edward J Novotny

  • 1Neuroradiology Section, Department of Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.

AJNR. American Journal of Neuroradiology
|June 16, 2005
PubMed
Summary

Metabolic ratios like n-acetylaspartate/creatine (NAA/Cr) and choline/creatine (Ch/Cr) vary across brain regions in healthy adults. However, these key MR spectroscopy values show no significant differences between sexes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ketone Bodies Derived From Medium-Chain Triglycerides Support Brain Metabolism and Function Under Hypoglycemia in Type 1 Diabetes Mellitus.

Diabetes·2026
Same author

Altering MRI rotating frame relaxations by changing the truncation level of Hyperbolic Secant pulse.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
Same author

Task-Evoked Functional Activation and Coupling With CSF Flow Detected in the Human Brain With Ultrashort Echo Time fMRI at 7 T.

NMR in biomedicine·2026
Same author

Reversible alterations of brain acetate metabolism associated with alcohol consumption.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

Q-MRS: Quantitative Magnetic Resonance Spectral Analysis Using Deep Learning.

NMR in biomedicine·2026
Same author

Recommendations for structural magnetic resonance imaging in infants with first afebrile seizure or new onset epilepsy: Evidence-based recommendations from the ILAE Neuroimaging Task Force.

Epilepsia·2026

Area of Science:

  • Neuroimaging
  • Magnetic Resonance Spectroscopy (MRS)
  • Human Brain Metabolism

Background:

  • Limited data exists on normal metabolic ratios using long echo time MR spectroscopy.
  • Establishing normative values is crucial for clinical applications in neurology.

Purpose of the Study:

  • To measure metabolic ratios in healthy adults using long echo time MR spectroscopy.
  • To investigate variations in these ratios across different brain regions and between sexes.

Main Methods:

  • Proton MR spectra acquired with a 135 ms echo time in 10 brain regions of 72 healthy adults (20-44 years).
  • Calculated ratios of n-acetylaspartate/creatine (NAA/Cr) and choline/creatine (Ch/Cr).
  • Utilized multifactorial analysis of variance and Scheffé F statistic for statistical analysis.

Related Experiment Videos

Main Results:

  • Significant regional variations observed for both NAA/Cr (P < .0001) and Ch/Cr (P < .0001) ratios.
  • NAA/Cr ratios differed between gray and white matter; Ch/Cr ratios showed variability within gray matter.
  • No statistically significant differences in metabolic ratios were found between male and female subjects.

Conclusions:

  • Metabolic ratios (NAA/Cr, Ch/Cr) exhibit regional variability in the adult brain but are not sex-dependent.
  • Provides essential normative data for interpreting long echo time MR spectroscopy in neurological disorders.