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Updated: Aug 17, 2026

Doppler Ultrasonography for Live Imaging and Quantification of Ovarian Vascular Function in Mice
Published on: November 14, 2025
Relaxin-induced angiogenesis in ovary contributes to follicle development
Kyoko Shirota1, Kayoko Tateishi, Makoto Emoto
1Department of Obstetrics and Gynecology, Fukuoka University School of Medicine, Fukuoka 814-0180, Japan.
Abstract:
CD31-positive blood vessels increased in human ovarian cortical tissues cultured with relaxin than in tissues cultured without relaxin. The number of vWF-positive vessels counted in rat ovaries after relaxin injection (40.5 +/- 4.3) significantly increased compared to that in saline-injected rats (24.3 +/- 3.0). The proportion of primordial follicles was significantly decreased, that of primary follicles was significantly increased at 16 h, and that of early antral follicles was significantly increased at 24 h in rats after relaxin injection. These results suggest that relaxin may contribute to follicle development through the mechanism of angiogenesis in the ovary.
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