Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New perspectives on parathyroid hormone therapy.

Nancy Lane1, Stephen Morris

  • 1University of California, Davis, Sacramento, California 95817, USA. Nancy.Lane@ucdmc.ucdavis.edu

Current Opinion in Rheumatology
|June 16, 2005
PubMed
Summary

Combining parathyroid hormone (PTH) with antiresorptive therapies offers new strategies for osteoporosis treatment. Sequential or combination approaches may improve fracture protection compared to single-agent therapies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"That's All We Wanted, to Be Heard, Listened to, Just to Be Validated and Believed": Family Experiences of Advocacy Support in Maternity and Neonatal Services.

Health expectations : an international journal of public participation in health care and health policy·2026
Same author

Alpha2 agonists for sedation to produce better outcomes for adults with critical illness: a synopsis of the A2B RCT with cost-effectiveness and process evaluation.

Health technology assessment (Winchester, England)·2026
Same author

Accelerated Vascular Ageing: An Early Prognostic Signal for Risk Stratification and Prevention.

European journal of preventive cardiology·2026
Same author

Optimising rapid prenatal exome sequencing in the NHS genomic medicine service: the EXPRESS Synopsis.

Health and social care delivery research·2026
Same author

Randomised controlled trial of a very brief nurse-delivered intervention followed by a digital intervention to support medication adherence and reduce blood pressure in people prescribed treatment for hypertension in primary care: protocol for the Programme on Adherence to Medication (PAM) trial.

NIHR open research·2026
Same author

Effectiveness and cost-effectiveness of a parenting programme to improve family wellbeing in England (TOGETHER): a multicentre, single-blind, randomised controlled trial.

The Lancet. Public health·2026

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Pharmacology

Background:

  • Osteoporosis treatment traditionally relies on antiresorptive agents.
  • Parathyroid hormone (PTH) is an anabolic agent that promotes bone formation, introducing new therapeutic strategies.

Purpose of the Study:

  • To review combination and sequential therapy approaches using PTH and antiresorptive agents.
  • To optimize treatment efficacy for osteoporosis.

Main Methods:

  • Review of existing literature on combination and sequential therapies for osteoporosis.
  • Analysis of treatment outcomes comparing anabolic and antiresorptive agents.

Main Results:

  • Combining or sequencing PTH with antiresorptives may offer superior fracture protection.
  • Transitioning from daily bisphosphonates to teriparatide may reduce efficacy.
  • Once-weekly bisphosphonates may be more compatible with PTH therapies.
  • Sequential PTH followed by antiresorptives aims to sustain efficacy gains.
  • Future PTH retreatment necessitates careful antiresorptive agent selection.
  • Different PTH formulations may impact combination and sequence outcomes.

Conclusions:

  • Combination and sequential therapies with PTH provide novel options for maximizing efficacy in osteoporosis patients.
  • These strategies aim to enhance fracture protection in individuals at risk.

Related Experiment Videos