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Updated: May 13, 2026
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Metabolic Labeling of Newly Transcribed RNA for High Resolution Gene Expression Profiling of RNA Synthesis, Processing and Decay in Cell Culture
Published on: August 8, 2013
Crosstalk between RNA metabolic pathways: an RNOMICS approach
Jean D Beggs1, David Tollervey
1Wellcome Trust Centre for Cell Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh EH9 3JR, UK. j.beggs@ed.ac.uk
Nature Reviews. Molecular Cell Biology
|June 16, 2005
Summary
Eukaryotic cells utilize complex RNA processing networks. The European RNOMICS project investigates how different RNA metabolism stages are coordinated, revealing functional links between processing pathways.
Area of Science:
- Molecular Biology
- Genetics
- Cell Biology
Background:
- Eukaryotic cells produce diverse RNA species, including messenger RNAs (mRNAs) and functional RNAs.
- Post-transcriptional processing is crucial for generating mature, functional RNA molecules.
- Emerging evidence suggests interconnectedness between various RNA processing pathways.
Purpose of the Study:
- To investigate functional links between different RNA processing pathways.
- To explore regulatory networks coordinating RNA metabolism stages.
- To present the European RNOMICS project's integrated approach and findings.
Main Methods:
- Integrated experimental approaches.
- Analysis of RNA processing pathways.
- Investigating regulatory networks in RNA metabolism.
Main Results:
- Accumulating evidence for functional links between RNA processing pathways.
- Identification of regulatory networks coordinating RNA metabolism.
- Preliminary results from the European RNOMICS project.
Conclusions:
- RNA processing pathways are functionally linked.
- Coordinated regulatory networks govern RNA metabolism.
- The RNOMICS project provides an integrated framework for studying these processes.
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