Focal segmental glomerulosclerosis associating Kimura disease.

Area of Science:

• Nephrology
• Pathology
• Dermatology

Background:

• Kimura disease is a rare, benign inflammatory condition characterized by subcutaneous masses.
• While primarily affecting skin and soft tissues, Kimura disease has a notable association with renal pathology.
• Understanding the extranodal manifestations of Kimura disease is crucial for comprehensive patient management.

Observation:

• A case of Kimura disease originating from western Asia was observed.
• The patient presented with nephrotic syndrome, a significant renal manifestation.
• The underlying renal pathology identified was focal segmental glomerulonephritis.

Findings:

• The case demonstrates an unusual presentation of Kimura disease.
• Focal segmental glomerulonephritis was diagnosed in a non-transplant kidney.
• This highlights the potential for Kimura disease to present with severe renal involvement.

Implications:

• This case expands the spectrum of renal manifestations associated with Kimura disease.
• It underscores the importance of considering Kimura disease in patients with unexplained nephrotic syndrome and glomerulonephritis.
• Further research into the pathogenesis of renal involvement in Kimura disease is warranted.