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Related Experiment Videos

Irritable esophagus.

J P Janssens1, G Vantrappen

  • 1Center for Gastrointestinal Research, University of Leuven, Belgium.

The American Journal of Medicine
|May 27, 1992
PubMed
Summary
This summary is machine-generated.

Noncardiac chest pain often originates in the esophagus. Studies identify acid-sensitive (20%), mechano-sensitive (14%), and irritable esophagus (24%) as key causes in patients with esophageal chest pain.

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Area of Science:

  • Gastroenterology
  • Esophageal Physiology
  • Pain Medicine

Background:

  • Noncardiac chest pain (NCCP) is frequently attributed to esophageal dysfunction.
  • The concept of an 'irritable esophagus' is used, but definitions vary.
  • Some define it as hypersensitivity to a single stimulus, while others describe a response to multiple stimuli.

Purpose of the Study:

  • To categorize patients with esophageal chest pain based on their response to specific stimuli.
  • To investigate the prevalence of different esophageal conditions contributing to NCCP.

Main Methods:

  • Utilized prolonged esophageal pH and pressure monitoring.
  • Employed provocative testing, including acid perfusion, edrophonium challenge, and intraesophageal balloon distention.

Related Experiment Videos

  • Classified patients into acid-sensitive, mechano-sensitive, or irritable esophagus groups.

    • Main Results:

    • Seven studies analyzed 281 NCCP patients.
    • Acid-sensitive esophagus was identified in 20% of patients.
    • Mechano-sensitive esophagus was found in 14% of patients.
    • Irritable esophagus (responding to multiple stimuli) was diagnosed in 24% of patients.

    Conclusions:

    • Esophageal origin is a significant factor in NCCP.
    • Categorizing patients based on stimulus response aids in understanding esophageal chest pain.
    • Acid sensitivity, mechanical sensitivity, and a combination (irritable esophagus) represent distinct pathophysiological entities in NCCP.