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Elevated levels of CRP in ovarian hyperstimulation syndrome: an unrecognised potential hazard?
Ishai Levin1, Ronni Gamzu, David Pauzner
1Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel.
Objective:
Elevated levels of C-reactive protein (CRP) were found recently to be a crucial marker for cardiovascular disease. This protein might have a role in endothelial cell activation, vascular damage and a thrombotic tendency. We sought to determine whether concentrations of CRP are altered in women with controlled ovarian hyperstimulation (COH) or hyperstimulation syndrome (OHSS).
Design:
A prospective cohort study.
Setting:
The gynecology department and IVF unit of the Lis maternity hospital.
Population:
Twenty women with OHSS, 20 women undergoing COH and 20 women who participated as controls were included in the study.
Methods:
Venous blood was withdrawn for analysis of high sensitive C-reactive protein (hs-CRP) using the Boering BN-II nephelometer.
Main Outcome Measures:
hs-CRP levels were determined.
Results:
There was a significant (P < 0.05) difference in the hs-CRP concentrations in women with OHSS compared with women with COH and controls. The respective values for hs-CRP were 19.0 [4.0], 7.0 [1.7] and 4.6 [1.1] mg/L.
Conclusions:
Women with OHSS have elevated concentrations of hs-CRP. This finding, previously believed to merely represent an acute phase response, may actually represent a yet unrecognised pathophysiological factor of this syndrome and pave the way for new investigational directions of this potentially hazardous condition.
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