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Updated: Aug 17, 2026

A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection
Published on: February 2, 2022
[Relationship between donor renal graft quality and graft rejection]
Li-xin Yu1, Jing-hua Zeng, Shao-jie Fu
1Department of Kidney Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. liuxy@fimmu.edu.cn
Objective:
To evaluate the correlation between the quality of donor renal grafts and graft rejection.
Methods:
The cold ischemia time and the pathological findings by biopsies of the donor grafts in 87 cases were analyzed in conjunction with the occurrence of acute or chronic graft rejection after transplantation.
Results:
After transplantation, acute rejection occurred in 28 cases, in which 5 (17.8%) had adverse changes in the donor grafts; chronic allograft nephropathy developed in 13 cases, in which 6 (46.1%) had adverse changes in the donor grafts. By binary logistic regression analysis, the cold ischemia time and acute renal tubular injury were identified as the factors affecting acute graft rejection, and cold ischemia time and glomeruloserosis as the risk factors for chronic rejection.
Conclusion:
High-quality donor kidney and minimization of the risk factors help reduce the occurrence of graft rejection after kidney transplantation.
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