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Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
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Published on: July 8, 2012

Involvement of proteases in cytokine-induced hematopoietic stem cell mobilization

Gerjo A Velders1, Willem E Fibbe

  • 1Department of Hematology, Leiden University Medical Center, Leiden, the Netherlands.

Annals of the New York Academy of Sciences
|June 17, 2005
PubMed

The number of circulating stem cells and progenitor cells can be increased by physiological stress, such as exercise, stress, and infections. The process of shifting the stem cells from the bone marrow into the peripheral blood is referred to as "mobilization" or "egress." Cytokine-mobilized hematopoietic progenitor cells (HPCs) are currently used for autologous or allogeneic stem cell transplantation in a variety of malignant and nonmalignant diseases. In spite of the wide-spread use of mobilized peripheral blood stem cells for transplantation, the mechanisms underlying mobilization are still incompletely understood. Here we discuss the role of neutrophils and proteases as mediators of stem cell mobilization.

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