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The stem cell continuum.

Peter J Quesenberry1, Gerald A Colvin, Mehrdad Abedi

  • 1Department of Research and Head, Cancer Center, Roger Williams Medical Center, 825 Chalkstone Ave., Providence, RI 02908-4735, USA. pquesenberry@rwmc.org

Annals of the New York Academy of Sciences
|June 17, 2005
PubMed
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Hematopoietic stem cells exhibit dynamic phenotypes, not fixed ones. Their differentiation potential and cell cycle phase influence hematopoietic and non-hematopoietic cell conversion.

Area of Science:

  • Stem Cell Biology
  • Developmental Biology
  • Cell Cycle Regulation

Background:

  • Hematopoietic stem cells (HSCs) were traditionally viewed as having a fixed hierarchical structure.
  • Recent research suggests HSC phenotype is heterogeneous and fluctuates.
  • Cell cycle phase influences HSC engraftment, adhesion, and gene expression.

Purpose of the Study:

  • To investigate the dynamic nature of HSC phenotype and differentiation potential.
  • To explore the relationship between cell cycle transit and HSC plasticity.
  • To determine if HSCs can differentiate into non-hematopoietic lineages.

Main Methods:

  • Utilized cytokine-induced cell cycle transit to study progenitor cell dynamics.
  • Employed a mouse transplant model to assess lung homing and conversion.

Related Experiment Videos

  • Analyzed HSC phenotype, differentiation potential, and cell cycle phase.

    • Main Results:

    • HSC progenitor numbers and differentiation potential vary reversibly with cell cycle.
    • Demonstrated significant conversion of marrow cells to skeletal muscle and lung cells.
    • Observed reversible fluctuations in lung homing and conversion correlating with cell cycle transit.

    Conclusions:

    • Marrow stem cells are regulated on a cell cycle-dependent continuum.
    • HSC plasticity extends to non-hematopoietic differentiation, influenced by cell cycle.
    • These findings challenge the fixed hierarchical model of stem cell differentiation.