Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dimethoate effects on thyroid function in suckling rats.

A Mahjoubi-Samet1, F Hamadi, L Soussia

  • 1Animal Physiology Laboratory, Life Sciences department, Sciences Faculty of Sfax, Route de la Soukra Km 3.5. BP 802. 3018 Sfax-Tunisie.

Annales D'Endocrinologie
|June 17, 2005
PubMed
Summary

Dimethoate exposure in drinking water significantly impairs thyroid function in both mothers and pups, leading to reduced body weight and altered thyroid hormone levels. This pesticide disrupts thyroid hormone production and iodine uptake, impacting overall health.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Occurrence and removal of intestinal parasites in two wastewater treatment plants in the south of Morocco.

Journal of environmental health science & engineering·2021
Same author

Coprological Survey of Protostrongylid Infections in Antelopes from Souss-Massa National Park (Morocco).

Helminthologia·2020
Same author

Beneficial role of vanillin, a polyphenolic flavoring agent, on maneb-induced oxidative stress, DNA damage, and liver histological changes in Swiss albino mice.

Human & experimental toxicology·2019
Same author

Penconazole alters redox status, cholinergic function, and membrane-bound ATPases in the cerebrum and cerebellum of adult rats.

Human & experimental toxicology·2016
Same author

Therapeutic efficacy of silymarin from milk thistle in reducing manganese-induced hepatic damage and apoptosis in rats.

Human & experimental toxicology·2012
Same author

Protein restriction in pregnant- and lactating rats-induced oxidative stress and hypohomocysteinaemia in their offspring.

Journal of animal physiology and animal nutrition·2009

Area of Science:

  • Environmental Toxicology
  • Endocrinology
  • Developmental Toxicology

Background:

  • Pesticides, such as dimethoate, are widely used, raising concerns about their potential impact on non-target organisms.
  • Thyroid hormones are crucial for growth, development, and metabolism in both mothers and offspring.

Purpose of the Study:

  • To investigate the effects of gestational and early postnatal exposure to dimethoate on thyroid function in rats.
  • To assess the impact of dimethoate on thyroid hormone levels, iodine uptake, and thyroid histology.

Main Methods:

  • Lactating rats and their pups were exposed to dimethoate (40 mg/kg/day) in drinking water from day 0 to day 10 postpartum.
  • Plasma levels of free thyroxine (T4), triiodothyronine (T3), and thyroid-stimulating hormone (TSH) were measured.

Related Experiment Videos

  • Thyroid iodine content and histological changes were examined in both dams and pups.

    • Main Results:

    • Dimethoate exposure led to a significant decrease in body weight in pups (48%) compared to controls.
    • Plasma free T4 and T3 levels were reduced in both pups and dams, with more pronounced effects in pups.
    • Thyroid iodine levels decreased significantly, accompanied by altered thyroid follicle morphology and elevated TSH levels.

    Conclusions:

    • Dimethoate exposure during lactation disrupts thyroid hormone homeostasis in both mothers and offspring.
    • The observed effects suggest that dimethoate interferes with thyroid hormone synthesis and/or release, potentially impacting development and metabolism.
    • These findings highlight the potential risks of dimethoate exposure to thyroid function and overall health.