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High bone mineral density among perimenopausal women
Janne Pesonen1, Joonas Sirola, Marjo Tuppurainen
1Bone and Cartilage Research Unit, Clinical Research Center, University of Kuopio, P.O. Box 1627, 70211, Kuopio, Finland. jhpesone@hytti.uku.fi
Summary
High bone mineral density (HBMD) in postmenopausal women is linked to being overweight, having children, hormone therapy, and adolescent physical activity. These women may have a lower fracture risk, reducing the need for bone density screening or osteoporosis medication.
Area of Science:
- Osteoporosis research
- Bone mineral density studies
Background:
- High bone mineral density (HBMD) studies are limited.
- Understanding HBMD predictors is crucial for fracture risk assessment.
Purpose of the Study:
- To identify predictors of persistently high bone mineral density (HBMD) in early postmenopausal women.
- To evaluate the fracture risk in women with HBMD.
Main Methods:
- Population-based study (Kuopio Osteoporosis Risk Factor and Prevention Study) with 1,551 women.
- Baseline and 5-year follow-up bone mineral density (BMD) measurements.
- Multivariate regression analysis to identify HBMD predictors.
Main Results:
- Predictors for HBMD included hormone therapy (HT) use, being overweight (BMI ≥ 25 kg/m²), parity (≥1 birth), and high physical activity in adolescence.
- Premenopausal status was more prevalent in the HBMD group.
- The HBMD group exhibited fewer fractures.
Conclusions:
- Overweight, parity, HT use, premenopause, and adolescent physical activity predict persistent HBMD in early postmenopausal women.
- Women with HBMD appear to have a low fracture risk.
- HBMD may indicate reduced need for BMD screening and osteoporosis medication.