Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Subtypes of autism by cluster analysis based on structural MRI data.

Michal Hrdlicka1, Iva Dudova, Irena Beranova

  • 1Department of Child Psychiatry, Charles University, 2nd Medical School, V Uvalu 84, 15006 Prague, Czech Republic.

European Child & Adolescent Psychiatry
|June 17, 2005
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical, in vitro, and in vivo evidence of WAPL as a cohesinopathy-associated gene and phenotypic driver of 10q22.3q23.2 genomic disorder.

American journal of human genetics·2026
Same author

Student-teacher agreement on personality traits and social competencies during early adolescence: A longitudinal study.

PloS one·2026
Same author

Novel Variants in KMT2C Further Support a Neurodevelopmental Disorder Distinct From Kleefstra and Kabuki Syndromes.

Molecular genetics & genomic medicine·2026
Same author

A More Precise Description of the AKT2-Related Hypoinsulinemic Hypoglycemia and Overgrowth Syndrome Phenotype, Formerly Described Under the MORFAN Acronym.

American journal of medical genetics. Part A·2026
Same author

Clinical, <i>in vitro</i>, and <i>in vivo</i> evidence of <i>WAPL</i> as a novel cohesinopathy gene and phenotypic driver of 10q22.3q23.2 genomic disorder.

medRxiv : the preprint server for health sciences·2026
Same author

Successful systemic phage therapy for implant-associated MRSA spondylodiscitis.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2026

This study used MRI data to identify four distinct subtypes of Autistic Spectrum Disorders (ASD). These subtypes, based on brain structure and clinical features, offer new ways to understand autism heterogeneity.

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Psychology

Background:

  • Autistic Spectrum Disorders (ASD) are complex neurodevelopmental conditions.
  • Current diagnostic criteria for ASD do not fully capture its heterogeneity.
  • Subtyping ASD is crucial for understanding underlying mechanisms and developing targeted interventions.

Purpose of the Study:

  • To subcategorize Autistic Spectrum Disorders (ASD) using a multidisciplinary approach.
  • To identify distinct patient clusters based on neuroimaging and clinical data.
  • To explore potential biological and clinical markers for ASD subtypes.

Main Methods:

  • Cluster analysis of MRI data from 64 autistic patients.
  • Utilized structural brain imaging (corpus callosum, amygdala, hippocampus, nucleus caudatus).

Related Experiment Videos

  • Correlated neuroimaging findings with clinical data (Childhood Autism Rating Scale, epilepsy, developmental history, facial dysmorphisms).

    • Main Results:

    • Four distinct clusters of ASD patients were identified.
    • Clusters differed in brain structure (e.g., corpus callosum, amygdala, hippocampus, nucleus caudatus sizes).
    • Clusters showed variations in clinical features including visual response, epilepsy, psychomotor development, and facial dysmorphisms, but not overall symptom severity.

    Conclusions:

    • A multidisciplinary approach integrating MRI and clinical data can effectively subtype ASD.
    • Identified ASD subtypes exhibit unique neuroanatomical and clinical profiles.
    • This subtyping method shows promise for advancing personalized medicine in autism research.