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Updated: Aug 17, 2026

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
Published on: July 22, 2020
The insulin-like growth factor system and colorectal cancer: clinical and experimental evidence
M Davies1, S Gupta, G Goldspink
1University Department of Surgery, Royal Free and University College Medical School, Rowland Hill Street, London, NW3 2PF, UK.
Objective:
The aim of this review is to clarify the involvement of the insulin-like growth factor (IGF) system in the development of colorectal malignancy.
Materials And Methods:
Medline searches were used to identify key articles relating the IGF system with the development of colorectal cancer.
Results:
The IGF system has been linked to colorectal malignancy by a convergence of data from epidemiological, clinical and laboratory-based sources.
Conclusion:
Further work is needed to characterise the IGF system expression in the colon. Such clarification could lead to the identification of targets that can be manipulated for clinical advantage.
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