Related Experiment Videos
Increased intestinal permeability in active pulmonary sarcoidosis
B Wallaert1, J F Colombel, A Adenis
1Service de Pneumologie et Immunoallergologie, Hôpital A. Calmette, Lille, France.
The American Review of Respiratory Disease
|June 1, 1992
Summary
Active pulmonary sarcoidosis increases intestinal permeability, similar to Crohn's disease. Inactive sarcoidosis shows normal gut permeability, unlike active disease.
Area of Science:
- Gastroenterology
- Pulmonology
- Immunology
Background:
- Altered intestinal permeability is characteristic of Crohn's disease.
- Pathological similarities exist between Crohn's disease and sarcoidosis.
- Gut mucosal lining integrity in pulmonary sarcoidosis requires investigation.
Purpose of the Study:
- To evaluate intestinal permeability in patients with pulmonary sarcoidosis.
- To compare intestinal permeability in active and inactive sarcoidosis.
- To assess the relationship between sarcoidosis and Crohn's disease gut permeability.
Main Methods:
- Intestinal permeability (IP) assessed using 24-h urinary excretion of 51Cr-ethylenediaminetetraacetic acid (51Cr-EDTA).
- Study included 18 patients with pulmonary sarcoidosis (active/inactive).
- Control groups comprised patients with Crohn's disease, tuberculosis, CWP, IPF, and healthy subjects.
Main Results:
- Active pulmonary sarcoidosis showed significantly increased IP (4 +/- 0.54%).
- Inactive sarcoidosis patients had normal IP (1.6 +/- 0.17%), similar to controls.
- Active Crohn's disease demonstrated markedly increased IP (7.7 +/- 1.4%), reduced in inactive disease.
Conclusions:
- Active pulmonary sarcoidosis is associated with increased intestinal permeability.
- Gut permeability is a potential biomarker differentiating active from inactive sarcoidosis.
- Findings suggest shared mechanisms in gut barrier dysfunction between sarcoidosis and Crohn's disease.