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Related Experiment Videos

[Endovascular microcoil applied for gene delivery system].

Lin Mei1, Hong-fan Sun, Li-na Tang

  • 1Tianjin Biomedical Material Key Laboratory, Institute of Biomedical Engineering, CAMS and PUMC, Tianjin 300192, China.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
|June 18, 2005
PubMed
Summary

This study demonstrates that endovascular microcoils can be modified for gene delivery. Modified microcoils successfully delivered adenovirus encoding green fluorescent protein (Ad-GFP) to arterial cells in rats, showing potential for device-based gene therapy.

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Area of Science:

  • Biomedical Engineering
  • Gene Therapy
  • Vascular Biology

Context:

  • Gene therapy offers potential for treating vascular diseases.
  • Current gene delivery methods face challenges in targeted delivery and efficiency.
  • Endovascular devices are increasingly used for therapeutic interventions.

Purpose:

  • To investigate the feasibility of utilizing endovascular microcoils as a platform for gene delivery.
  • To functionalize microcoils with antibodies to tether adenoviral vectors.
  • To evaluate the efficacy and biodistribution of gene delivery using modified microcoils in a rat arterial model.

Summary:

  • Anti-adenoviral antibodies were covalently attached to platinum microcoils, which then tethered adenovirus encoding green fluorescent protein (Ad-GFP).

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  • In vitro studies showed transduction of smooth muscle cells on the microcoil surface.
  • In vivo, gene-modified microcoils implanted in rat carotid arteries resulted in successful transduction of cells within the thrombus, with no detectable viral spread to major organs.

    • Impact:

    • This research establishes endovascular microcoils as a viable device-based platform for targeted gene therapy.
    • The findings suggest potential for single or multiple gene vector delivery systems.
    • This approach could lead to novel interventional strategies for vascular diseases.