Related Experiment Video
Updated: Aug 17, 2026

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
Published on: June 6, 2025
A single compartment neuron model with activity-dependent conductances during NMDA induced activity
Małgorzata Baszczak1, Stefan Kasicki
1Department of Neurophysiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., 02-093 Warsaw, Poland.
Abstract:
In most neuron models the values of maximal conductances of membrane ionic currents are fixed. In our paper we investigate spiking activity of the neuron model activated tonically by NMDA synapse, when the membrane ionic currents are dynamically dependent on calcium concentration, as in a model by Abbott and coauthors (1993). A spiking neuron model (in Matlab/Simulink environment) is based on the properties of lamprey spinal neurons. The basic neuron is a one-compartment model with voltage-gated Na+, K, Ca2+, KCa+ channels. The Na+ and K+ currents are described with the dynamic equations of Hodgkin-Huxley model (Hodgkin and Huxley 1952). The Ca2+ and KCa+ channels are modeled using description of calcium dynamic introduced by Ekeberg and coauthors (1991). The model was tonically activated by NMDA synapse described by a kinetic model of synaptic transmission. We analyzed the activity of this model and showed that when only one of conductances is calcium-dependent, the cell is not able to react to and recover from external perturbations.
Related Concept Videos
The Role of Ion Channels in Neuronal Computation
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential.
Action Potentials
Action Potential
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Action Potential
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Neural Circuits
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Ligand-Gated Ion Channel Receptor: Gating Mechanism

