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[Hurthle cell neoplasm: our experience].

M G Cristofaro1, G Vescio, M G Fava

  • 1Università degli Studi di Catanzaro.

Annali Italiani Di Chirurgia
|June 18, 2005
PubMed
Summary
This summary is machine-generated.

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Hurthle cell neoplasms are rare thyroid tumors that are difficult to distinguish from benign nodules. Accurate histology is crucial for diagnosis and treatment, guiding surgical choices and adjuvant therapies.

Area of Science:

  • Endocrinology
  • Oncology
  • Pathology

Context:

  • Hurthle cell neoplasms represent a rare subset of thyroid tumors, accounting for 1.5% to 10% of all thyroidal neoplasms.
  • Clinically, Hurthle cell nodules are often indistinguishable from other common nodular thyroid diseases, posing diagnostic challenges.

Purpose:

  • To highlight the diagnostic difficulties associated with Hurthle cell neoplasms.
  • To emphasize the necessity of accurate histologic evaluation for correct diagnosis and therapeutic planning.
  • To outline recommended surgical and adjuvant treatment strategies for Hurthle cell adenomas and carcinomas.

Summary:

  • Histologic features of Hurthle cell neoplasms often preclude definitive distinction between benign (adenomas) and malignant (carcinomas) entities.
  • Adenomas typically show a follicular pattern, while carcinomas encompass variants with diverse biological behaviors, including follicular and papillary types.

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  • Recommended surgical management includes total thyroidectomy for carcinomas and lobectomy plus isthmusectomy for adenomas. Lymphadenectomy is indicated for carcinomas with lymph node involvement to reduce local recurrence.

    • Impact:

    • Accurate histologic assessment is paramount for appropriate patient management and therapeutic selection.
    • Surgical interventions, including thyroidectomy and lymphadenectomy, are tailored to the specific diagnosis (adenoma vs. carcinoma).
    • Adjuvant radiation therapy demonstrates efficacy in preventing recurrences and managing symptomatic metastases, improving outcomes for advanced or recurrent disease.